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pi3k ko mice  (Hubner GmbH)

 
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    Hubner GmbH pi3k ko mice
    Pi3k Ko Mice, supplied by Hubner GmbH, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/pi3k ko mice/product/Hubner GmbH
    Average 90 stars, based on 1 article reviews
    pi3k ko mice - by Bioz Stars, 2026-03
    90/100 stars

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    <t>PI3K,</t> phosphoinositide 3-kinase; TLR, toll-like receptor; HDM, house dust mite; WT, wild type; KO, knock-out; NHBE, normal human bronchial epithelial; SAL + VEH, saline-instilled mice with administered with vehicle; HDM + VEH, HDM-instilled mice administered with vehicle; HDM + IC 0.1, HDM-instilled mice administered with 0.1 mg/kg of IC87114; HDM + IC 1.0, HDM-instilled mice administered with 1.0 mg/kg of IC87114; WT + HDM, WT mice instilled with HDM; PKO + HDM, PI3K-δ KO mice instilled with HDM; NF-κB, nuclear factor-κB; LPS, lipopolysaccharide; CON siRNA, control scrambled siRNA; R.D., relative density. * P < 0.05 vs. HDM + VEH, HDM + CON siRNA, LPS + VEH or WT + HDM; † P < 0.05 vs. SAL + VEH or Control.
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    Image Search Results


    PI3K, phosphoinositide 3-kinase; TLR, toll-like receptor; HDM, house dust mite; WT, wild type; KO, knock-out; NHBE, normal human bronchial epithelial; SAL + VEH, saline-instilled mice with administered with vehicle; HDM + VEH, HDM-instilled mice administered with vehicle; HDM + IC 0.1, HDM-instilled mice administered with 0.1 mg/kg of IC87114; HDM + IC 1.0, HDM-instilled mice administered with 1.0 mg/kg of IC87114; WT + HDM, WT mice instilled with HDM; PKO + HDM, PI3K-δ KO mice instilled with HDM; NF-κB, nuclear factor-κB; LPS, lipopolysaccharide; CON siRNA, control scrambled siRNA; R.D., relative density. * P < 0.05 vs. HDM + VEH, HDM + CON siRNA, LPS + VEH or WT + HDM; † P < 0.05 vs. SAL + VEH or Control.

    Journal: Allergy, Asthma & Immunology Research

    Article Title: Epithelial PI3K-δ Promotes House Dust Mite-Induced Allergic Asthma in NLRP3 Inflammasome-Dependent and -Independent Manners

    doi: 10.4168/aair.2020.12.2.338

    Figure Lengend Snippet: PI3K, phosphoinositide 3-kinase; TLR, toll-like receptor; HDM, house dust mite; WT, wild type; KO, knock-out; NHBE, normal human bronchial epithelial; SAL + VEH, saline-instilled mice with administered with vehicle; HDM + VEH, HDM-instilled mice administered with vehicle; HDM + IC 0.1, HDM-instilled mice administered with 0.1 mg/kg of IC87114; HDM + IC 1.0, HDM-instilled mice administered with 1.0 mg/kg of IC87114; WT + HDM, WT mice instilled with HDM; PKO + HDM, PI3K-δ KO mice instilled with HDM; NF-κB, nuclear factor-κB; LPS, lipopolysaccharide; CON siRNA, control scrambled siRNA; R.D., relative density. * P < 0.05 vs. HDM + VEH, HDM + CON siRNA, LPS + VEH or WT + HDM; † P < 0.05 vs. SAL + VEH or Control.

    Article Snippet: In addition, Cas9 RNA-guided endonuclease (RGEN) PI3K-δ KO mice (Macrogen, Inc., Seoul, Korea) were used, and they were interbred and maintained up to 8–10 weeks of age in pathogen-free condition at Macrogen, Inc.

    Techniques: Knock-Out

    PI3K, phosphoinositide 3-kinase; IL, interleukin; HDM, house dust mite; WT, wild type; KO, knock-out; PI3KD siRNA, siRNA targeting PI3K-δ isoform; CON siRNA, control scrambled siRNA; BAL, bronchoalveolar lavage; HDM + VEH, HDM-instilled mice administered with vehicle; WT + HDM, WT mice instilled with HDM; SAL + VEH, saline-instilled mice with administered with vehicle; SAL, saline-instilled mice; HDM + IC 0.1, HDM-instilled mice administered with 0.1 mg/kg of IC87114; HDM + IC 1.0, HDM-instilled mice administered with 1.0 mg/kg of IC87114; PKO + HDM, PI3K-δ KO mice instilled with HDM; R.D., relative density. * P < 0.05 vs. HDM + VEH, WT + HDM, or HDM + CON siRNA; † P < 0.05 vs. SAL + VEH or SAL + SAL.

    Journal: Allergy, Asthma & Immunology Research

    Article Title: Epithelial PI3K-δ Promotes House Dust Mite-Induced Allergic Asthma in NLRP3 Inflammasome-Dependent and -Independent Manners

    doi: 10.4168/aair.2020.12.2.338

    Figure Lengend Snippet: PI3K, phosphoinositide 3-kinase; IL, interleukin; HDM, house dust mite; WT, wild type; KO, knock-out; PI3KD siRNA, siRNA targeting PI3K-δ isoform; CON siRNA, control scrambled siRNA; BAL, bronchoalveolar lavage; HDM + VEH, HDM-instilled mice administered with vehicle; WT + HDM, WT mice instilled with HDM; SAL + VEH, saline-instilled mice with administered with vehicle; SAL, saline-instilled mice; HDM + IC 0.1, HDM-instilled mice administered with 0.1 mg/kg of IC87114; HDM + IC 1.0, HDM-instilled mice administered with 1.0 mg/kg of IC87114; PKO + HDM, PI3K-δ KO mice instilled with HDM; R.D., relative density. * P < 0.05 vs. HDM + VEH, WT + HDM, or HDM + CON siRNA; † P < 0.05 vs. SAL + VEH or SAL + SAL.

    Article Snippet: In addition, Cas9 RNA-guided endonuclease (RGEN) PI3K-δ KO mice (Macrogen, Inc., Seoul, Korea) were used, and they were interbred and maintained up to 8–10 weeks of age in pathogen-free condition at Macrogen, Inc.

    Techniques: Knock-Out

    PI3K, phosphoinositide 3-kinase; HDM, house dust mite; BAL, bronchoalveolar lavage; CON, control mice; VEH, vehicle; DAPI, 4′,6-diamidino-2-phenylindole; SAL + VEH, saline-instilled mice with administered with vehicle; HDM + VEH, HDM-instilled mice administered with vehicle; HDM + IC 0.1, HDM-instilled mice administered with 0.1 mg/kg of IC87114; HDM + IC 1.0, HDM-instilled mice administered with 1.0 mg/kg of IC87114.

    Journal: Allergy, Asthma & Immunology Research

    Article Title: Epithelial PI3K-δ Promotes House Dust Mite-Induced Allergic Asthma in NLRP3 Inflammasome-Dependent and -Independent Manners

    doi: 10.4168/aair.2020.12.2.338

    Figure Lengend Snippet: PI3K, phosphoinositide 3-kinase; HDM, house dust mite; BAL, bronchoalveolar lavage; CON, control mice; VEH, vehicle; DAPI, 4′,6-diamidino-2-phenylindole; SAL + VEH, saline-instilled mice with administered with vehicle; HDM + VEH, HDM-instilled mice administered with vehicle; HDM + IC 0.1, HDM-instilled mice administered with 0.1 mg/kg of IC87114; HDM + IC 1.0, HDM-instilled mice administered with 1.0 mg/kg of IC87114.

    Article Snippet: In addition, Cas9 RNA-guided endonuclease (RGEN) PI3K-δ KO mice (Macrogen, Inc., Seoul, Korea) were used, and they were interbred and maintained up to 8–10 weeks of age in pathogen-free condition at Macrogen, Inc.

    Techniques:

    NF-κB, nuclear factor-κB; ROS, reactive oxygen species; HDM, house dust mite; SEM, standard error of the mean; BAL, bronchoalveolar lavage; DAPI, 4′,6-diamidino-2-phenylindole; PI3K, phosphoinositide 3-kinase; SAL + VEH, saline-instilled mice with administered with vehicle; HDM + VEH, HDM-instilled mice administered with vehicle; HDM + IC 0.1, HDM-instilled mice administered with 0.1 mg/kg of IC87114; HDM + IC 1.0, HDM-instilled mice administered with 1.0 mg/kg of IC87114; WT + HDM, WT mice instilled with HDM; PKO + HDM, PI3K-δ KO mice instilled with HDM; R.D., relative density; IL, interleukin; PAMP, pathogen-associated molecular pattern molecule. * P < 0.05 vs. HDM + VEH; † P < 0.05 vs. SAL + VEH; ‡ P < 0.05 vs. WT + HDM.

    Journal: Allergy, Asthma & Immunology Research

    Article Title: Epithelial PI3K-δ Promotes House Dust Mite-Induced Allergic Asthma in NLRP3 Inflammasome-Dependent and -Independent Manners

    doi: 10.4168/aair.2020.12.2.338

    Figure Lengend Snippet: NF-κB, nuclear factor-κB; ROS, reactive oxygen species; HDM, house dust mite; SEM, standard error of the mean; BAL, bronchoalveolar lavage; DAPI, 4′,6-diamidino-2-phenylindole; PI3K, phosphoinositide 3-kinase; SAL + VEH, saline-instilled mice with administered with vehicle; HDM + VEH, HDM-instilled mice administered with vehicle; HDM + IC 0.1, HDM-instilled mice administered with 0.1 mg/kg of IC87114; HDM + IC 1.0, HDM-instilled mice administered with 1.0 mg/kg of IC87114; WT + HDM, WT mice instilled with HDM; PKO + HDM, PI3K-δ KO mice instilled with HDM; R.D., relative density; IL, interleukin; PAMP, pathogen-associated molecular pattern molecule. * P < 0.05 vs. HDM + VEH; † P < 0.05 vs. SAL + VEH; ‡ P < 0.05 vs. WT + HDM.

    Article Snippet: In addition, Cas9 RNA-guided endonuclease (RGEN) PI3K-δ KO mice (Macrogen, Inc., Seoul, Korea) were used, and they were interbred and maintained up to 8–10 weeks of age in pathogen-free condition at Macrogen, Inc.

    Techniques:

    PI3K, phosphoinositide 3-kinase; HDM, house dust mite; BAL, bronchoalveolar lavage; H&E, haematoxylin and eosin; IL, Interleukin; TNF-α, tumor necrosis factor-α; SAL + VEH, saline-instilled mice with administered with vehicle; HDM + VEH, HDM-instilled mice administered with vehicle; HDM + IC 0.1, HDM-instilled mice administered with 0.1 mg/kg of IC87114; HDM + IC 1.0, HDM-instilled mice administered with 1.0 mg/kg of IC87114; WT + HDM, wild type mice instilled with HDM; PKO + HDM, PI3K-δ knock-out mice instilled with HDM; R.D., relative density; MAC, macrophage; EOS, eosinophil; NEU, neutrophil; LYM, lymphocyte. * P < 0.05 vs. HDM + VEH or WT + HDM; † P < 0.05 vs. SAL + VEH.

    Journal: Allergy, Asthma & Immunology Research

    Article Title: Epithelial PI3K-δ Promotes House Dust Mite-Induced Allergic Asthma in NLRP3 Inflammasome-Dependent and -Independent Manners

    doi: 10.4168/aair.2020.12.2.338

    Figure Lengend Snippet: PI3K, phosphoinositide 3-kinase; HDM, house dust mite; BAL, bronchoalveolar lavage; H&E, haematoxylin and eosin; IL, Interleukin; TNF-α, tumor necrosis factor-α; SAL + VEH, saline-instilled mice with administered with vehicle; HDM + VEH, HDM-instilled mice administered with vehicle; HDM + IC 0.1, HDM-instilled mice administered with 0.1 mg/kg of IC87114; HDM + IC 1.0, HDM-instilled mice administered with 1.0 mg/kg of IC87114; WT + HDM, wild type mice instilled with HDM; PKO + HDM, PI3K-δ knock-out mice instilled with HDM; R.D., relative density; MAC, macrophage; EOS, eosinophil; NEU, neutrophil; LYM, lymphocyte. * P < 0.05 vs. HDM + VEH or WT + HDM; † P < 0.05 vs. SAL + VEH.

    Article Snippet: In addition, Cas9 RNA-guided endonuclease (RGEN) PI3K-δ KO mice (Macrogen, Inc., Seoul, Korea) were used, and they were interbred and maintained up to 8–10 weeks of age in pathogen-free condition at Macrogen, Inc.

    Techniques: Knock-Out

    HDM, house dust mite; PI3K, phosphoinositide 3-kinase; BAL, bronchoalveolar lavage; H&E, haematoxylin and eosin; IL, interleukin; CON siRNA, control scrambled siRNA; HDM + VEH, HDM-instilled mice administered with vehicle; SAL, saline-instilled mice; SAL + VEH, saline-instilled mice with administered with vehicle; PI3KD siRNA, siRNA targeting PI3K-δ isoform; R.D., relative density; MAC, macrophage; EOS, eosinophil; NEU, neutrophil; LYM, lymphocyte. * P < 0.05 vs. HDM + CON siRNA or HDM + VEH; † P < 0.05 vs. SAL + SAL or SAL + VEH.

    Journal: Allergy, Asthma & Immunology Research

    Article Title: Epithelial PI3K-δ Promotes House Dust Mite-Induced Allergic Asthma in NLRP3 Inflammasome-Dependent and -Independent Manners

    doi: 10.4168/aair.2020.12.2.338

    Figure Lengend Snippet: HDM, house dust mite; PI3K, phosphoinositide 3-kinase; BAL, bronchoalveolar lavage; H&E, haematoxylin and eosin; IL, interleukin; CON siRNA, control scrambled siRNA; HDM + VEH, HDM-instilled mice administered with vehicle; SAL, saline-instilled mice; SAL + VEH, saline-instilled mice with administered with vehicle; PI3KD siRNA, siRNA targeting PI3K-δ isoform; R.D., relative density; MAC, macrophage; EOS, eosinophil; NEU, neutrophil; LYM, lymphocyte. * P < 0.05 vs. HDM + CON siRNA or HDM + VEH; † P < 0.05 vs. SAL + SAL or SAL + VEH.

    Article Snippet: In addition, Cas9 RNA-guided endonuclease (RGEN) PI3K-δ KO mice (Macrogen, Inc., Seoul, Korea) were used, and they were interbred and maintained up to 8–10 weeks of age in pathogen-free condition at Macrogen, Inc.

    Techniques:

    IL, interleukin; LPS, lipopolysaccharide; HDM, house dust mite; WT, wild type; KO, knock-out; TSLP, thymic stromal lymphopoietin; NHBE, normal human bronchial epithelial; WT + HDM, WT mice instilled with HDM; PI3K, phosphoinositide 3-kinase; PKO + HDM, PI3K-δ KO mice instilled with HDM; CON siRNA, control scrambled siRNA; R.D., relative density. * P < 0.05 vs. WT + HDM; † P < 0.05 vs. Control.

    Journal: Allergy, Asthma & Immunology Research

    Article Title: Epithelial PI3K-δ Promotes House Dust Mite-Induced Allergic Asthma in NLRP3 Inflammasome-Dependent and -Independent Manners

    doi: 10.4168/aair.2020.12.2.338

    Figure Lengend Snippet: IL, interleukin; LPS, lipopolysaccharide; HDM, house dust mite; WT, wild type; KO, knock-out; TSLP, thymic stromal lymphopoietin; NHBE, normal human bronchial epithelial; WT + HDM, WT mice instilled with HDM; PI3K, phosphoinositide 3-kinase; PKO + HDM, PI3K-δ KO mice instilled with HDM; CON siRNA, control scrambled siRNA; R.D., relative density. * P < 0.05 vs. WT + HDM; † P < 0.05 vs. Control.

    Article Snippet: In addition, Cas9 RNA-guided endonuclease (RGEN) PI3K-δ KO mice (Macrogen, Inc., Seoul, Korea) were used, and they were interbred and maintained up to 8–10 weeks of age in pathogen-free condition at Macrogen, Inc.

    Techniques: Knock-Out